Frequency of Positive Endometrial Pipelle Biopsies in Patients with Abnormal Uterine Bleeding for Detection of Endometrial Carcinoma

Aim: To determine frequency of positive endometrial biopsies in pre and post menopausal patients with abnormal uterine bleeding for detection of endometrial carcinoma. Methods: This Cross-sectional study was conducted at Gynecological outpatient department Nishtar Hospital Multan from January 2013 to December 2013. Pre and post-menopausal women between 3570 years with abnormal uterine bleeding fulfilling inclusion criteria were selected for the study. After detailed history and examination, informed consent, pipelle endometrial biopsy was taken. Biopsy of each patient was labeled and sent to histopathology department of Nishtar Hospital Multan for histopathology. Results: Among 126 patients, majority (38.09%) were in age group 35-45 years and were multipara. 58.73% patients were post-menopausal and menorrhagia was the most frequent presenting complaint. Amount of tissue obtained on curetting with Pipelle was adequate in 96.82% of cases. The most frequent histopathology finding on pipelle endometrial sampling was secretary endometrium i.e., in 38.88% of cases. Endometrial biopsy for carcinoma was positive in only 5.55% of cases. Conclusion: Pipelle biopsy is definitely a useful and cost-effective method. It can reduce the number of D &Cs performed in the operating theatre. The accuracy of the Pipelle is higher in postmenopausal women compared with premenopausal women.